Coagulaçao

COAGULAÇAO

Informaçao  geral

Directorios

http://emedicine.medscape.com/hematology

http://www.netwellness.org/healthtopics/

http://www.pathologyoutlines.com/coagulation.html

Textos

https://en.wikipedia.org/wiki/Coagulation

http://www.strokecenter.org/professionals/brain-anatomy/atherosclerosis-and-thrombus-formation/thrombus-formation-iiiactivation-of-coagulation-cascade/

http://themedicalbiochemistrypage.org/blood-coagulation.html

http://ocw.tufts.edu/Content/24/labs/312447

http://www.frca.co.uk/article.aspx?articleid=100096#int

http://www.blobs.org/science/article.php?article=14

https://www.rndsystems.com/pathways/blood-coagulation-signaling-pathways

http://atvb.ahajournals.org/content/27/8/1687.full

http://www.merckmanuals.com/home/blood-disorders/blood-clotting-process/how-blood-clots

http://www.wfh.org/en/page.aspx?pid=635

Genetica da coagulação

http://www.hhmi.org/research/molecular-genetics-blood-clotting

http://blog.23andme.com/23andme-research/snpwatch/snpwatch-genetic-variants-may-reduce-ability-of-anti-clotting-drug-clopidogrel-to-prevent-a-second-heart-attack/

http://www.ihtc.org/patient/blood-disorders/clotting-disorders/inherited-causes-of-thrombosis/

http://www.chla.org/genetic-clotting-disorders

http://www.hhmi.org/research/molecular-genetics-blood-clotting

http://blog.23andme.com/health-traits/three-genes-for-blood-clots/

http://www.revespcardiol.org/en/the-genetic-component-of-disorders/articulo/13146059

Informaçao especializada

Activador do plasminogenio tecidular

https://en.wikipedia.org/wiki/Tissue_plasminogen_activator

https://www.nlm.nih.gov/medlineplus/ency/article/007089.htm

http://www.nejm.org/doi/full/10.1056/NEJM199512143332401

http://atvb.ahajournals.org/content/29/8/1151.full

Deficiencia em activador do plasminogenio

Ver inibidores da actividade do plasminogenio

Agregaçao plaquetaria

http://www.pharmacorama.com/Rubriques/Output/Coagulationa2.php

http://www.ncbi.nlm.nih.gov/books/NBK53449/

https://www.nlm.nih.gov/medlineplus/ency/article/003669.htm

http://www.healthline.com/health/platelet-aggregation-test#ReadThisNext7

http://www.bloodjournal.org/content/109/12/5087?sso-checked=true

Antiplasmina ( inibidor da plasmina)

https://en.wikipedia.org/wiki/Alpha_2-antiplasmin

http://www.rightdiagnosis.com/a/anti_plasmin_deficiency_congenital/intro.htm

http://circ.ahajournals.org/content/95/7/1886.full

http://emedicine.medscape.com/article/198336-overview

http://practical-haemostasis.com/Fibrinolysis/a2pi.html

https://www.hemophilia.org/sites/default/files/document/files/A2AntiplasminAndItsDeficiency.pdf

http://www.rarecoagulationdisorders.org/diseases/alpha-2-antiplasmin-deficiency/disease-overview

http://www.haemtech.com/Inhibitors_Substrates/HA2AP.htm

http://www.rightdiagnosis.com/a/anti_plasmin_deficiency_congenital/intro.htm

Antitrombina

http://emedicine.medscape.com/article/198573-overview

https://en.wikipedia.org/wiki/Antithrombin

https://www.nlm.nih.gov/medlineplus/ency/article/003661.htm

http://www.healthline.com/health/antithrombin-iii

Deficiencia em antitrombina

http://emedicine.medscape.com/article/954688-overview

https://www.nlm.nih.gov/medlineplus/ency/article/000558.htm

http://ghr.nlm.nih.gov/condition/hereditary-antithrombin-deficiency

https://www.stoptheclot.org/antithrombin-deficiency.htm

http://rarediseases.org/rare-diseases/antithrombin-deficiency/

Bernard- Soulier

http://omim.org/entry/231200

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC296685/?tool=pmcentrez

https://en.wikipedia.org/wiki/Bernard%E2%80%93Soulier_syndrome

http://emedicine.medscape.com/article/954877-overview

http://www.medicinenet.com/bernard-soulier_disease/article.htm

http://www.wfh.org/en/page.aspx?pid=657

http://doencasraras.tripod.com/id13.html

http://www.bloodjournal.org/content/91/12/4397?sso-checked=true

Bradiquinina

https://en.wikipedia.org/wiki/Bradykinin

http://www.pharmacorama.com/en/Sections/Angiotensin_2.php

http://circ.ahajournals.org/content/95/5/1115.full

http://www.jneurosci.org/content/25/35/7986.full

http://www.jneurosci.org/content/25/35/7986.fullf

http://www.hellenicjcardiol.com/archive/full_text/2012/2/2012_2_91.pdf

Receptor da bradiquinina

https://en.wikipedia.org/wiki/Bradykinin_receptor

http://www.ebi.ac.uk/interpro/entry/IPR001504

http://www.omim.org/entry/1135030

Buerger

Ver trombangeite obliterante

Calicreina

https://en.wikipedia.org/wiki/Kallikrein

https://en.wikipedia.org/wiki/Kinin%E2%80%93kallikrein_system

http://www.nature.com/nrd/journal/v14/n3/abs/nrd4534.html

Christmas

http://emedicine.medscape.com/article/199088-overview

https://en.wikipedia.org/wiki/Factor_IX

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372679/

http://web.expasy.org/spotlight/back_issues/041/

http://www.ebi.ac.uk/pdbe/quips?story=XmasFactor~

Deficiência  do factor Christmas – hemofilis B

http://rarediseases.about.com/cs/hemophilia/a/122100.htm

https://www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Hemophilia-B

http://emedicine.medscape.com/article/199088-overview

http://patient.info/doctor/haemophilia-b-factor-ix-deficiency

https://www.nlm.nih.gov/medlineplus/ency/article/000539.htm

http://ghr.nlm.nih.gov/gene/F9

http://www.bio.davidson.edu/Courses/Molbio/MolStudents/spring2003/WoodC/coag.html

Coagulaçao e gravidez

http://www.gfmer.ch/Obstetrics_simplified/Coagulation_defects_in_pregnancy.htm

http://americanpregnancy.org/pregnancy-complications/blood-clots-during-pregnancy/

http://www.babycentre.co.uk/a1048412/thrombosis-in-pregnancy

https://en.wikipedia.org/wiki/Hypercoagulability_in_pregnancy

http://www.thebump.com/a/blood-clot-during-pregnancy

https://www.openanesthesia.org/aba_coagulation_changes_in_pregnancy/

 http://www.clotconnect.org/patients/what-do-i-need-to-know/i-m-a-woman-who-has-experienced-pregnancy-loss

http://www.marchofdimes.org/complications/blood-clots-and-pregnancy.aspx#

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2425447/

Coagulaçao  intravascular disseminada

http://emedicine.medscape.com/article/199627-overview

http://www.myvmc.com/diseases/disseminated-intravascular-coagulation/

https://www.nlm.nih.gov/medlineplus/ency/article/000573.htm

https://en.wikipedia.org/wiki/Disseminated_intravascular_coagulation

 

https://www.merckmanuals.com/professional/hematology-and-oncology/coagulation-disorders/disseminated-intravascular-coagulation-(dic)

http://www.healthline.com/health/disseminated-intravascular-coagulation-dic

http://patient.info/doctor/disseminated-intravascular-coagulation

Cofactor II da heparina

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150836/

http://www.haemtech.com/Inhibitors_Substrates/HCII.htm

http://www.omim.org/entry/612356

http://www.omim.org/entry/142360

http://www.archivesofpathology.org/doi/pdf/10.1043/0003-9985(2002)126%3C1394%3AHCID%3E2.0.CO%3B2

Dermatite purpúrica pigmentada

http://emedicine.medscape.com/article/1084594-overview

http://patient.info/doctor/pigmented-purpuric-dermatoses

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412251/

http://www.dermnetnz.org/vascular/capillaritis.html

http://www.aocd.org/?page=ProgressivePigmenta

Fibrina

https://en.wikipedia.org/wiki/Fibrin

http://pdb101.rcsb.org/motm/83

Factores da coagulaçso

https://en.wikipedia.org/wiki/Coagulation

http://www.clotbase.bicnirrh.res.in/flow_ln.php

http://www.essentialhaematology6.com/tables/chapter24.pdf

http://www.hindawi.com/journals/iji/2011/367284/

http://faculty.ucc.edu/biology-potter/hemostasis.htm

FACTOR	NAME	SOURCE	PATHWAY
I	Fibrinogen	Liver	Common
II	Prothrombin (enzyme)	Liver *	Common
III	Thromboplastin	Released by damaged cells	Extrinsic
III	Thromboplastin	Released by platelets	Intrinsic
IV	Calcium ions	Bone and gut	Entire process
V	Proaccererin     (heat labile cofactor)	Liver and Platelets	Extrinsic and Intrinsic
VII	Proconvertin (enzyme)	Liver *	Extrinsic
VIII	Anti-hemolytic factor(cofactor)	Platelets and endothelium	Intrinsic
IX	Christmas factor(plasma thromboplastin component)	Liver *	Intrinsic
X	Stuart Prower factor (enzyme)	Liver *	Extrinsic and Intrinsic
XI	Plasma thromboplastin antecedent (enzyme)	Liver	Intrinsic
XII	Hageman factor	Liver	Intrinsic; also activates plasmin
XIII	Fibrin stabilizing factor	Liver	Retards fibrinolysis

*vitamin K dependente

Factor III, factor tecidular ou  tromboplastina

https://en.wikipedia.org/wiki/Tissue_factor

http://theoncologist.alphamedpress.org/content/11/7/849.full

http://www.omim.org/entry/134390

Deficiencia em factor III

http://emedicine.medscape.com/article/954688-overview

https://en.wikipedia.org/wiki/Antithrombin_III_deficiency

Factor IV

http://www.dovemed.com/common-procedures/procedures-laboratory/factor-iv-calcium-coagulation-blood-test/

Factor V (Leiden)

https://www.nlm.nih.gov/medlineplus/ency/article/000550.htm

http://circ.ahajournals.org/content/107/7/1003.full?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=factor+V&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

http://emedicine.medscape.com/article/209492-overview

http://www.hemophilia.ca/en/bleeding-disorders/other-

https://en.wikipedia.org/wiki/Factor_V_Leiden

http://www.mayoclinic.org/diseases-conditions/factor-v-leiden/basics/definition/con-20032637

Deficiencia em fsactor V

http://ghr.nlm.nih.gov/gene/F5

http://www.healthline.com/health/factor-v-deficiency

http://emedicine.medscape.com/article/209492-overview

http://www.omim.org/entry/612309

Trombofilia do  factor V

Ver TROMBOFILIS

Factor VII ou proconvertina

http://emedicine.medscape.com/article/209585-overview

https://en.wikipedia.org/wiki/Factor_VII

Deficiencia em factor VII

http://www.healthline.com/health/factor-vii-deficiency

https://www.nlm.nih.gov/medlineplus/ency/article/000548.htm

https://www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies/Factor-VII

http://www.wfh.org/en/page.aspx?pid=665

Factor VIIa

http://factorviia.com/

http://www.fda.gov/downloads/.../ucm056915.pdf

http://www.mayoclinic.org/drugs-supplements/coagulation-factor-viia-intravenous-route/description/drg-20063784

http://www.drugs.com/cdi/coagulation-factor-viia-recombinant.html

Factor VIII

http://emedicine.medscape.com/article/779322-overview

https://en.wikipedia.org/wiki/Factor_VIII

http://www.bloodjournal.org/content/92/11/3983

http://ghr.nlm.nih.gov/gene/F8

Deficiencia do factor VIII

https://www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Hemophilia-A

http://emedicine.medscape.com/article/779322-overview

http://patient.info/doctor/haemophilia-a-factor-viii-deficiency

Factor VIII aumentado

http://atvb.ahajournals.org/content/21/5/731.full

  

Factor IX ( Christmas)

.Ver CHRISTMAS

Factor X ( Stuart – Power)

http://emedicine.medscape.com/article/209867-overview

https://en.wikipedia.org/wiki/Factor_X

https://www.nlm.nih.gov/medlineplus/ency/article/000553.htm

Deficiencia em factor X

http://emedicine.medscape.com/article/209867-overview

http://www.healthline.com/health/factor-x-deficiency

https://www.nlm.nih.gov/medlineplus/ency/article/000553.htm

http://ghr.nlm.nih.gov/condition/factor-x-deficiency

http://www.wfh.org/en/page.aspx?pid=661

http://www.hemophilia.ca/en/bleeding-disorders/other-factor-deficiencies/factor-x-deficiency/

http://www.omim.org/entry/227600

http://www.bloodjournal.org/content/97/6/1885?sso-checked=true

Factor Xa

http://www.enamine.net/index.php?option=com_content&task=view&id=52

https://www.thrombosisadviser.com/en/_thrombosis/factor-xa/

http://www.pnas.org/content/80/19/6086.full.pdf

Factor XI

http://emedicine.medscape.com/article/209984-overview

Drficiencia em  factor XI

https://en.wikipedia.org/wiki/Factor_XI

http://ghr.nlm.nih.gov/gene/F11

http://www.wfh.org/en/page.aspx?pid=660

http://emedicine.medscape.com/article/209984-overview

http://rarediseases.org/rare-diseases/factor-xi-deficiency/

https://www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies/Factor-XI

http://www.hemophilia.ca/en/bleeding-disorders/other-factor-deficiencies/factor-xi-deficiency--hemophilia-c/

https://www.counsyl.com/services/family-prep-screen/diseases/factor-xi-deficiency/.

Factor XII ( Hageman)

https://en.wikipedia.org/wiki/Factor_XII

https://www.nlm.nih.gov/medlineplus/ency/article/000545.htm

http://www.rightdiagnosis.com/h/hageman_factor_deficiency/intro.ht

http://ghr.nlm.nih.gov/gene/F12

http://www.bloodjournal.org/content/120/22/4296

 

Deficiencia em  factor XII

http://rarediseases.org/rare-diseases/factor-xii-deficiency/

https://www.nlm.nih.gov/medlineplus/ency/article/000545.htm

http://www.hemophilia.ca/files/Factor_XII_Deficiency.pdf

Factor XIII

http://www.rightdiagnosis.com/h/hageman_factor_deficiency/intro.htm

https://en.wikipedia.org/wiki/Factor_XIII

https://www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies/Factor-XIII

http://factorxiii.org/0

http://emedicine.medscape.com/article/960515-overview

http://www.bloodjournal.org/content/100/3/743?sso-checked=true

Deficiencia bem factor XIII

https://en.wikipedia.org/wiki/Factor_XIII_deficiency

http://rarediseases.org/rare-diseases/factor-xiii-deficiency/

http://www.wfh.org/en/page.aspx?pid=664

Fibrinogenio

https://www.nlm.nih.gov/medlineplus/ency/article/003650.htm

http://www.drkaslow.com/html/fibrinogen.html

http://www.ebi.ac.uk/interpro/potm/2006_11/Page2.htm

https://en.wikipedia.org/wiki/Fibrinogen

https://www.nlm.nih.gov/medlineplus/ency/article/003650.htm

http://emedicine.medscape.com/article/2085501-overview

https://labtestsonline.org/understanding/analytes/fibrinogen/tab/test/

https://www.ebi.ac.uk/interpro/potm/2006_11/Page1.htm

http://www.britannica.com/science/fibrinogen

http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/8484

Deficiencia em fibrinogenio

http://www.hemophilia.ca/en/bleeding-disorders/other-factor-deficiencies/factor-i-

http://www.wfh.org/en/page.aspx?pid=659

 http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=335

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762433/

http://www.cslbehring.com/products/inherited-bleeding-disorders-congenital-fibrinogen-factor-I-deficiency.htm

Fibrinolise

http://www.pharmacorama.com/Rubriques/Output/Coagulationa6.php

https://www.nlm.nih.gov/medlineplus/ency/article/000577.htm

https://www.boundless.com/physiology/textbooks/boundless-anatomy-and-physiology-textbook/blood-17/hemostasis-168/fibrinolysis-842-1162/

http://williams.medicine.wisc.edu/fibrinolysis.pdf

Hemofilia

https://www.google.pt/search?q=plasmin&oq=plasmin&aqs=chrome..69i57j69i60.14783j0j7&sourceid=chrome&es_sm=93&ie=UTF-8#q=hemophilia

·         Haemophilia A is a recessive X-linked genetic disorder involving a lack of functional clotting Factor VIII and represents 80% of haemophilia cases.

·         Haemophilia B is a recessive X-linked genetic disorder involving a lack of functional clotting Factor IX. It comprises approximately 20% of haemophilia cases.^[11]

·         Haemophilia C is an autosomal genetic disorder (i.e. not X-linked) involving a lack of functional clotting Factor XI. Haemophilia C is not completely recessive, asheterozygous individuals also show increased bleeding.^[12]

http://www.mayoclinic.org/diseases-conditions/hemophilia/basics/definition/con-20029824

http://www.nhlbi.nih.gov/health/health-topics/topics/hemophili

http://www.medicinenet.com/hemophilia/article.htm

http://www.cdc.gov/ncbddd/hemophilia/facts.html

http://kidshealth.org/en/teens/hemophilia.html

https://www.genome.gov/20019697

http://www.medicalnewstoday.com/info/hemophilia/

Hipercoagulaçao

https://my.clevelandclinic.org/services/heart/disorders/blood-clotting

http://www.heart.org/HEARTORG/Conditions/More/What-Is-Excessive-Blood-Clotting-Hypercoagulation_UCM_448768_Article.jsp#.Vs7zz5yLTIU

http://www.encyclopedia.com/topic/Hypercoagulation_Disorders.aspx

https://my.clevelandclinic.org/services/heart/disorders/blood-clotting

http://www.anapsid.org/CND/diffdx/hypercoagulation.html

http://familydoctor.org/familydoctor/en/diseases-conditions/hypercoagulation/causes-risk-factors.html

http://www.diagnose-me.com/symptoms-of/hypercoagulation-thickened-blood.php

Homocistinemia e coagulação

http://www.pathologyoutlines.com/topic/coagulationhyperhomocysteinemia.html

http://circ.ahajournals.org/content/111/19/e289.full

http://link.springer.com/chapter/10.1007%2F978-94-017-1789-2_20#page-1

http://onlinelibrary.wiley.com/doi/10.1111/j.1538-7836.2004.00674.x/pdf

Inibidor da plasmina (antiplasmina)

.http://www.haemtech.com/Inhibitors_Substrates/HA2AP.htm

https://en.wikipedia.org/wiki/Alpha_2-antiplasmin

Deficiencia da antiplasmina

http://emedicine.medscape.com/article/198336-overview

Inibidores da via do factor tecidular

https://en.wikipedia.org/wiki/Tissue_factor_pathway_inhibitor

http://www.sciencedirect.com/science/article/pii/S1658361209700769

https://www.ebi.ac.uk/interpro/potm/2006_3/Page2.htm

http://www.bloodjournal.org/content/101/11/4387?sso-checked=true

http://williams.medicine.wisc.edu/tfpi.pdf

http://www.omim.org/entry/152310

Alfa 2 Macroglobulina

https://en.wikipedia.org/wiki/Alpha-2-Macroglobulin

Deficiencia em alfa2 macroglobulina

http://www.omim.org/entry/103950

May- Hegglin

http://emedicine.medscape.com/article/956447-overview

http://rarediseases.org/rare-diseases/may-hegglin-anomaly/

https://en.wikipedia.org/wiki/May%E2%80%93Hegglin_anomaly

http://www.omim.org/entry/155100

http://www.rightdiagnosis.com/m/may_hegglin_anomaly/intro.htm

https://www.orpha.net/data/patho/Pro/en/MYH9RelatedPlatelet-FRenPro18198v01.pdf

http://www.bloodjournal.org/content/119/2/328?sso-checked=true

http://faoj.org/2008/09/01/may-hegglin-and-other-platelet-dysfunctions-as-complications-to-compartment-syndrome-a-case-report/

Plaquetas

http://emedicine.medscape.com/article/956447-overview

https://en.wikipedia.org/wiki/Platelet

https://www.nlm.nih.gov/medlineplus/ency/article/003647.htm

http://www.ouhsc.edu/platelets/Platelets/platelets%20intro.html

http://emedicine.medscape.com/article/201722-overview

http://www.hopkinsmedicine.org/heart_vascular_institute/clinical_services/centers_excellence/womens_cardiovascular_health_center/patient_information/health_topics/platelets.ht

Plasmina

https://en.wikipedia.org/wiki/Plasmin

http://www.enzymeresearch.com/product/human-plasmin/

Plasminogenio

http://emedicine.medscape.com/article/2085859-overview

http://www.practical-haemostasis.com/Fibrinolysis/plasminogen.html

Activaçao do plasminogenio

https://en.wikipedia.org/wiki/Tissue_plasminogen_activator

http://stroke.ahajournals.org/content/41/10_suppl_1/S39.full

Deficiencia em plasminogenio

http://www.rarecoagulationdisorders.org/diseases/plasminogen-deficiency/disease-overview

http://ghr.nlm.nih.gov/condition/congenital-plasminogen-deficiency

http://www.omim.org/entry/217090

https://www.hemophilia.org/sites/default/files/document/files/PlasminogenDeficiency.pdf

http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=PT&data_id=8694&Disease_Disease_Search_diseaseGroup=plasminogen&Disease_Disease_Search_diseaseType=Pat&Disease(s)%20concerned=Hypoplasminogenemia--Plasminogen-deficiency--type-1-&title=Hypoplasminogenemia--Plasminogen-deficiency--type-1-&search=Disease_Search_Simple

http://www.rarecoagulationdisorders.org/diseases/plasminogen-deficiency/disease-overview

Inibidor do activador do plasminogenio

https://en.wikipedia.org/wiki/Plasminogen_activator_inhibitor-1

https://en.wikipedia.org/wiki/Plasminogen_activator_inhibitor-2

https://carcin.oxfordjournals.org/content/29/4/824.abstract

https://carcin.oxfordjournals.org/content/29/11/2236.abstra

Pre-calicreina

https://en.wikipedia.org/wiki/Prekallikrein

http://www.pnas.org/content/73/11/4179.full.pdf

http://www.jbc.org/content/261/1/324.full.pdf

Deficiencia em pre-calicreina

http://ghr.nlm.nih.gov/condition/prekallikrein-deficiency

http://www.ncbi.nlm.nih.gov/pubmed/21091145

http://www.omim.org/entry/612423

http://www.hindawi.com/journals/crihem/2012/723204/

http://www.pathologyoutlines.com/topic/coagulationprekallekreindef.html

Proteinas C e S

https://en.wikipedia.org/wiki/Protein_C

https://en.wikipedia.org/wiki/Protein_S

https://www.nlm.nih.gov/medlineplus/ency/article/003660.htm

https://labtestsonline.org/understanding/analytes/protein-c-and-s/tab/test/

Deficiencia em proteínas C

http://patient.info/doctor/protein-c-deficiency

https://www.nlm.nih.gov/medlineplus/ency

http://emedicine.medscape.com/article/205470-ov

Deficiencia congénita em proteínas C e S

https://www.nlm.nih.gov/medlineplus/ency/article/000559.htm

http://circ.ahajournals.org/content/124/14/e365.full

http://www.pathologyoutlines.com/topic/coagulationproteinCS.html

Deficiencia em proteína S

https://en.wikipedia.org/wiki/Protein_S_deficiency

https://rarediseases.info.nih.gov/gard/4524/diseas

http://emedicine.medscape.com/article/205582-overview

https://www.nlm.nih.gov/medlineplus/ency/article/000559.htm

Proteina Z

https://en.wikipedia.org/wiki/Protein_Z

Deficiencia em proteína Z

http://www.bloodjournal.org/content/99/7/2606

http://www.bloodjournal.org/content/111/10/4973

http://www.omim.org/entry/614024

http://stroke.ahajournals.org/content/35/6/1329.full.pdf

Protrombina

http://www.britannica.com/science/prothrombin

Deficiencia em protrombina

https://www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies/Factor-II

http://ghr.nlm.nih.gov/condition/prothrombin-deficiency

http://emedicine.medscape.com/article/209742-overview

http://www.healthline.com/health/factor-ii-deficiency#

http://www.omim.org/entry/613679

http://www.wfh.org/en/page.aspx?pid=666

https://www.hemophilia.org/sites/default/files/document/files/AbnormalitiesOfProthrombin.pdf

Mutaçao do gene da protrombina

http://circ.ahajournals.org/content/110/3/e15.full

http://www.healthcare.uiowa.edu/labs/lentz/Information_For_Patients/PDF/Prothrombin%20Gene%20Mutation%20Brochure.pdf

http://www.melbournehaematology.com.au/fact-sheets/prothrombin-gene-mutation.html

Tempo de protrombina

https://www.nlm.0nih.gov/medlineplus/ency/ar

https://en.wikipedia.org/wiki/Prothrombin_time

http://www.webmd.com/a-to-z-guides/prothrombin-time

http://www.mayoclinic.org/tests-procedures/prothrombin-time/details/results/rsc-20163828

https://labtestsonline.org/understanding/analytes/pt/tab/test/

http://www.healthline.com/health/prothrombin-time-pt

http://www.practical-haemostasis.com/Screening%20Tests/pt.html

http://www.clinchem.org/content/54/4/765.full

http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/9236

Purpura

https://en.wikipedia.org/wiki/Purpura

Purpura actínica

http://www.aocd.org/?page=BruisingHandsAndArms

http://emedicine.medscape.com/article/1087008-overview

http://emedicine.medscape.com/article/1087008-treatment

Purpura de Bateman ou purpura senil

http://www.skinsite.com/info_bateman_s_purpura.htm

http://www.dermnetnz.org/vascular/senile-purpura.html

http://www.vulgaris-medical.com/encyclopedie-medicale/purpura-de-bateman

http://www.bozemanskinclinic.com/skin-conditions/batemans-purpura.php

http://www.skinsite.com/info_bateman_s_purpura.htm

http://link.springer.com/chapter/10.1385%2F1-59259-906-0%3A219#page-1

http://www.disabled-world.com/health/dermatology/skin/bruising-limbs.php

http://dermatologytimes.modernmedicine.com/dermatology-times/news/modernmedicine/modern-medicine-feature-articles/oral-medication-clears-senile?page=full

http://www.medicalnewstoday.com/articles/318805.php?utm_source=newsletter&utm_medium=email&utm_campaign=daily-hcp

Purpura fulminans

http://www.medicalnewstoday.com/releases/22033.php

http://emedicine.medscape.com/article/2202749-overview

https://en.wikipedia.org/wiki/Purpura_fulminans

http://bja.oxfordjournals.org/content/86/4/581.full

http://www.ijdvl.com/article.asp?issn=0378-6323;year=2012;volume=78;issue=2;spage=228;epage=228;aulast=Talwar

Purpura de Henoch- Schonlein

http://www.aafp.org/afp/1998/0801/p405.html

http://www.medicinenet.com/henoch-schonlein_purpura/article.htm

https://en.wikipedia.org/wiki/Henoch%E2%80%93Sch%C3%B6nlein_purpura

http://emedicine.medscape.com/article/984105-overview

http://www.webmd.com/skin-problems-and-treatments/henoch-schonlein-purpura-causes-symptoms-treatment

http://www.sbp.com.br/arquivo/purpura-de-henoch-schonlein/

http://www.mayoclinic.org/diseases-conditions/henoch-schonlein-purpura/basics/definition/con-20028291

http://www.medicalnewstoday.com/articles/318948.php?utm_source=newsletter&utm_medium=email&utm_campaign=daily-hcp

Purpura de Henoch-Schonlein associada  doença de Graves

https://ndt.oxfordjournals.org/content/21/10/2997.2.full

Purpura trombocitogenica idiopática

http://emedicine.medscape.com/article/779545-overview

https://www.nlm.nih.gov/medlineplus/ency/article/000535.htm

http://www.netdoctor.co.uk/conditions/heart-and-blood/a1176/idiopathic-thrombocytopenic-purpura-itp/

http://www.mayoclinic.org/diseases-conditions/henoch-schonlein-purpura/basics/definition/con-20028291

https://en.wikipedia.org/wiki/Immune_thrombocytopenic_purpura

http://patient.info/health/immune-thrombocytopenia-leaflet

http://rarediseases.org/rare-diseases/immune-thrombocytopenia/

https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/idiopathic-thrombocytopenic-purpura-itp

Purpura trombocitopénica imune

http://www.stanfordchildrens.org/en/topic/default?id=immune-idiopathic-thrombocytopenia-purpura-90-P02315

http://www.nhlbi.nih.gov/health/health-topics/topics/itp/

http://emedicine.medscape.com/article/202158-overview

https://en.wikipedia.org/wiki/Thrombotic_thrombocytopenic_purpura

Purpura trombocitopénica trombótica

http://emedicine.medscape.com/article/206598-overview

https://www.nlm.nih.gov/medlineplus/ency/artic

http://ghr.nlm.nih.gov/condition/thrombotic-thrombocytopenic-purpura

https://en.wikipedia.org/wiki/Thrombotic_thrombocytopenic_purpura

http://www.healthline.com/health/thrombotic-thrombocytopenic-purpura

http://www.bcshguidelines.com/documents/BJH_TTP_Guideline_0512.pdf

http://patient.info/doctor/thrombotic-thrombocytopenic-purpura

http://www.merckmanuals.com/professional/hematology-and-oncology/thrombocytopenia-and-platelet-dysfunction/thrombotic-thrombocytopenic-purpura-(ttp)-and-hemolytic-uremic-syndrome-(hus)

Quininogenio de alto peso molecular

https://en.wikipedia.org/wiki/High-molecular-weight_kininogen

http://www.pnas.org/content/74/10/4636.full.pdf

http://www.bloodjournal.org/content/bloodjournal/48/6/941.full.pdf?sso-checked=true

http://www.bloodjournal.org/content/91/2/516

Deficiencia do quininogenio de alto peso molecular~

http://www.omim.org/entry/228960

http://www.pathologyoutlines.com/topic/coagulationHMWKdef.html

http://www.bloodjournal.org/content/101/11/4430

Sindroma de anticorpos antifosfolipidos

http://emedicine.medscape.com/article/333221-overview

http://www.mayoclinic.org/diseases-conditions/antiphospholipid-syndrome/basics/definition/con-20028805

https://www.nhlbi.nih.gov/health/health-topics/topics/aps

https://en.wikipedia.org/wiki/Antiphospholipid_syndrome

http://www.medicinenet.com/antiphospholipid_syndrome/article.htm

http://www.apsfa.org/aps.htm

https://labtestsonline.org/understanding/analytes/antiphospholipids/tab/test/

http://emedicine.medscape.com/article/2116457-overview

Terapia trombolitica

http://emedicine.medscape.com/article/811234-overview

http://emedicine.medscape.com/article/1160840-overview

https://www.nlm.nih.gov/medlineplus/ency/artic

https://en.wikipedia.org/wiki/Thrombolytic_dru

http://circ.ahajournals.org/content/94/5/1167.full

https://www.vascularweb.org/vascularhealth/Pages/thrombolytic-therapy.aspx

http://www.webmd.com/stroke/guide/thrombolysis-definition-and-facts

http://www.surgeryencyclopedia.com/St-Wr/Thrombolytic-Therapy.html

Trombangeite obliterante  ou doença de Buerger

http://emedicine.medscape.com/article/460027-overview

https://www.nlm.nih.gov/medlineplus/ency/article/000172.htm

https://en.wikipedia.org/wiki/Thromboangiitis_obliterans

http://circ.ahajournals.org/content/121/16/1858.full

http://www.mayoclinic.org/diseases-conditions/buergers-disease/home/ovc-20179160

http://www.hindawi.com/journals/iji/2013/156905/

http://ojrd.biomedcentral.com/articles/10.1186/1750-1172-1-14

http://www.healthline.com/health/thromboangiitis-obliterans#Overview1

Trombastenia de Glanzman

http://emedicine.medscape.com/article/200311-overv

https://en.wikipedia.org/wiki/Glanzmann%27s_thrombasthenia

http://www.wfh.org/en/page.aspx?pid=658

http://rarediseases.org/rare-diseases/glanzmann-thrombasthenia/

http://www.omim.org/entry/273800

https://www.nlm.nih.gov/medlineplus/ency/article/001305.htm

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475837/

http://www.healthline.com/health/glanzmanns-disease

http://www.hemophilia.ca/files/engGT.pdf

http://emedicine.medscape.com/article/955385-treatment

Trombina

https://en.wikipedia.org/wiki/Thrombin

http://pdb101.rcsb.org/motm/25

http://www.britannica.com/science/thrombin

http://www.haemtech.com/enzymes/thrombin.htm

Trombocitopenia

https://www.nlm.nih.gov/medlineplus/ency/article/000586.htm

http://www.netdoctor.co.uk/conditions/heart-and-blood/a1177/thrombocytopenia-reduced-platelet-count/

http://www.merckmanuals.com/home/blood-disorders/platelet-disorders/thrombocytopenia-itp-ttp

http://emedicine.medscape.com/article/201722-overview

http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/hematology-oncology/disorders-platelet-function/

http://www.webmd.com/a-to-z-guides/thrombocytopenia-symptoms-causes-treatments

http://www.mayoclinic.org/diseases-conditions/thrombocytopenia/basics/definition/

con-20027170

https://en.wikipedia.org/wiki/Thrombocytopenia

http://www.medicinenet.com/thrombocytopenia_low_platelet_count/article.htm

http://www.emedicinehealth.com/thrombocytopenia_low_platelet_count/article_em.htm

http://www.cancer.net/navigating-cancer-care/side-effects/thrombocytopenia

Plaquetaferese

https://en.wikipedia.org/wiki/Plateletpheresis

http://lanebloodcenter.org/can-i-donate/plateletpheresis/

https://www.aabb.org/advocacy/government/public/Documents/katz.pdf

http://www.sciencedirect.com/science/article/pii/S1473050213002802

http://www.fda.gov/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/Blood/ucm073382.htm

Transfusao de plaquetas

http://annals.org/article.aspx?articleid=1930861

http://reference.medscape.com/drug/platelets-999506

http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2003.04468.x/pdf

http://asheducationbook.hematologylibrary.org/content/2007/1/172.full

Trombo

http://www.medicalnewstoday.com/articles/318522.php?utm_source=newsletter&utm_medium=email&utm_campaign=daily-hcp

https://en.wikipedia.org/wiki/Thrombus

https://www.thrombosisadviser.com/thrombus-formation

https://www.webmd.com/dvt/venous-thrombus-and-embolus

https://www.webmd.com/dvt/venous-thrombus-and-embolus

https://www.sciencedirect.com/topics/neuroscience/thrombus

Trombocitopenia autoimune

http://emedicine.medscape.com/article/202158-overview

http://www.nhlbi.nih.gov/health/health-topics/topics/thcp/causes

http://www.hopkinsarthritis.org/physician-corner/rheumatology-rounds/round-8-autoimmune-thrombocytopenia/

https://www.nhlbi.nih.gov/health/health-topics/topics/itp

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905072/

https://en.wikipedia.org/wiki/Immune_thrombocytopenic_purpura

http://patient.info/health/immune-thrombocytopenia-leaflet

http://www.rightdiagnosis.com/a/autoimmune_thrombocytopenia/intro.htm

Trombocitopenia induzida pela heparina

https://en.wikipedia.org/wiki/Heparin-induced_thrombocytopenia

http://www.bloodjournal.org/content/112/7/2607.full?sso-checked=true

http://thrombosisjournal.biomedcentral.com/articles/10.1186/1477-9560-3-14

http://www.thedoctorsdoctor.com/diseases/heparin_induced_thrombocytopenia.htm

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600013/

http://circ.ahajournals.org/content/114/8/e355.full

https://www.clevelandclinicmeded.com/medicalpubs/pharmacy/septoct2001/thrombocytopenia.htm

http://www.bcshguidelines.com/documents/HIT_2012.pdf

http://www.medicinenet.com/script/main/art.asp?articlekey=14278

http://content.onlinejacc.org/article.aspx?articleid=1124564

Trombocitose

http://emedicine.medscape.com/article/959378-overview

http://www.netdoctor.co.uk/conditions/heart-and-blood/a1183/thrombocytosis-and-essential-thrombocythaemia/

http://patient.info/doctor/thrombocytosis

http://www.mayoclinic.org/diseases-conditions/thrombocytosis/basics/definition/con-20032674

https://my.clevelandclinic.org/health/diseases_conditions/hic_Thrombocytosis

https://en.wikipedia.org/wiki/Thrombocytosis

Trombocitose essencial

https://en.wikipedia.org/wiki/Essential_thrombocytosis

http://emedicine.medscape.com/article/206697-overview~

http://rarediseases.org/rare-diseases/essential-thrombocythemia/

http://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/essential-thrombocythemia

http://www.mpnresearchfoundation.org/Essential-Thrombocythemia

https://ghr.nlm.nih.gov/condition/essential-thrombocythemia

https://my.clevelandclinic.org/health/diseases_conditions/hic_Thrombocytosis

https://www.lls.org/sites/default/files/file_assets/essentialprimarythrombocythemia.pdf

Trombocitose secundaria

https://en.wikipedia.org/wiki/Essential_thrombocytosis

http://emedicine.medscape.com/article/206811-overview

https://www.nhlbi.nih.gov/health/health-topics/topics/thrm/causes

https://my.clevelandclinic.org/health/diseases_conditions/hic_Thrombocytosis

http://www.mayoclinic.org/diseases-conditions/thrombocytosis/basics/causes/con-20032674

http://patient.info/doctor/thrombocytosis0

http://www.ascopost.com/media/160413/3.5.43_fig1.jpg

Trombofilia

https://en.wikipedia.org/wiki/Thrombophilia

http://emedicine.medscape.com/article/211039-overview

http://www.nhs.uk/Conditions/thrombophilia/Pages/Thrombophilia.aspx

http://patient.info/health/thrombophilia-leaflet

http://patient.info/doctor/thrombophilia-pro

https://ghr.nlm.nih.gov/condition/prothrombin-thrombophilia

https://www.stoptheclot.org/article143.htm

https://www.stoptheclot.org/thrombophilias.htm

http://patientblog.clotconnect.org/2010/11/19/thrombophilia-testing-%E2%80%93-who-should-be-tested/

http://www.ncbi.nlm.nih.gov/books/NBK1368/

http://ghr.nlm.nih.gov/condition/factor-v-

Trombolise dirigida por catetero

http://www.radiologyinfo.org/en/info.cfm?pg=thromb

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036379/

http://emedicine.medscape.com/article/1921338-overview

http://atvb.ahajournals.org/content/30/4/669.full

http://archinte.jamanetwork.com/article.aspx?articleid=1889011

https://eu-csite-storage-prod.s3.amazonaws.com/www-cirse-org/files/files/SOP/2011/SOP_CIRSE_2011_Percutaneous%20Catheter-Directed%20Intra-Arterial%20Thrombolysis%20and%20Mechanical%20Thrombectomy%20for%20Acute%20Lower-Limb%20Ischemia.pdf

http://www.tctmd.com/show.aspx?id=124866

Trombomodulina

https://en.wikipedia.org/wiki/Thrombomodulin

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC553573/

http://www.gefaesse.at/download/11_aktuelle_literatur-06-03-2012/Thrombomodulin-as-a-regulator-of-the-anticoagulant-pathway-Implication-in-the-development-of---1.pdf

http://www.bloodjournal.org/content/93/10/3442?sso-checked=true

http://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-19-342

http://www.hindawi.com/journals/ccrp/2012/614545/fig4/

Trombopoietina

https://en.wikipedia.org/wiki/Thrombopoietin

http://www.priory.com/med/thrombo.htm

http://theoncologist.alphamedpress.org/content/1/1/98.full

http://www.cancernetwork.com/cancer-complications/thrombopoietin-biology-and-potential-clinical-applications

http://physiologyonline.physiology.org/content/17/1/6

http://www.thrombocyte.com/thrombopoietin0/

Trombose

https://www.nlm.nih.gov/medlineplus/ency/article/001124.htm

http://www.rightdiagnosis.com/t/thrombosis/

https://en.wikipedia.org/wiki/Thrombosis

http://www.news-medical.net/health/What-is-Thrombosis.aspx

http://www.thrombosisuk.org/home.php

Trombose da artéria basilar

http://emedicine.medscape.com/article/1161044-overview

.http://radiopaedia.org/articles/acute-basilar-artery-occlusion

http://stroke.ahajournals.org/content/27/8/1301.full

http://jnnp.bmj.com/content/74/12/1621.full

http://stroke.ahajournals.org/content/21/8/1135.full.pdf

http://archneur.jamanetwork.com/article.aspx?articleid=781746

http://www.ajnr.org/content/18/7/1221.full.pdf

Trombose coronária

http://emedicine.medscape.com/article/1161044-overview

http://www.rawfoodexplained.com/diseases-relating-to-the-heart/coronary-thrombosis.html

https://en.wikipedia.org/wiki/Coronary_thrombosis

http://www.netdoctor.co.uk/conditions/heart-and-blood/a1140/coronary-thrombosis-heart-attack/

https://www.thrombosisadviser.com/en/acs/a-leading-cause-of-mortality/

http://circ.ahajournals.org/content/90/5/2315.abstract

http://www.nhs.uk/Conditions/arterial-thrombosis/Pages/Introduction.aspx

http://heartattacknew.com/faq/how-dangerous-are-my-blocked-coronary-arteries/acute-blockage/

Trombose portal

http://www.merckmanuals.com/home/liver-and-gallbladder-disorders/blood-vessel-disorders-of-the-liver/veno-occlusive-disease-of-the-liver

https://en.wikipedia.org/wiki/Portal_vein_thrombosis

http://emedicine.medscape.com/article/182425-overview

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104181/

http://radiopaedia.org/articles/portal-vein-thrombosis

http://www.jabfm.org/content/21/3/237.full

Budd – Chiari

https://en.wikipedia.org/wiki/Budd%E2%80%93Chiari_syndrome

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.02742.x/full

http://www.ncbi.nlm.nih.gov/books/NBK1271/

http://www.merckmanuals.com/home/liver-and-gallbladder-disorders/blood-vessel-disorders-of-the-liver/budd-chiari-syndrome

https://www.blogger.com/home?pli=1

http://emedicine.medscape.com/article/184430-overview

http://www.medscape.com/viewarticle/777005

https://www.med.upenn.edu/gastro/documents/NewEnglandJournalBCS.pdf

http://patient.info/doctor/budd-chiari-syndrome-pro

http://www.chp.edu/our-services/transplant/liver/education/liver-disease-states/budd-chiari-syndrome

Trombose das veias profundas

http://www.emedicinehealth.com/blood_clot_in_the_legs/article_em.htm

http://www.sirweb.org/patients/deep-vein-thrombosis/

https://en.wikipedia.org/wiki/Deep_vein_thrombosis

http://www.medicinenet.com/deep_vein_thrombosis/article.htm

https://www.nlm.nih.gov/medlineplus/ency/article/000

http://orthoinfo.aaos.org/topic.cfm?topic=a00219

http://www.mayoclinic.org/diseases-conditions/deep-vein-thrombosis/basics/definition/con-20031922

http://www.webmd.com/dvt/deep-vein-thrombosis-dvt-symptoms-diagnosis

http://www.webmd.com/dvt/deep-vein-thrombosis-causes-are-you-risk-dvt

http://www.nhlbi.nih.gov/health/health-topics/topics/dvt/

http://www.healthline.com/health/deep-venous-thrombosis

http://www.medicinenet.com/deep_vein_thrombosis/article.htm

http://circ.ahajournals.org/content/93/12/2212.full

http://www.cdc.gov/ncbddd/dvt/facts.html

https://www.nlm.nih.gov/medlineplus/ency/article/000156.htm

Trombose venosa cerebral

http://emedicine.medscape.com/article/1162804-overview

http://stroke.ahajournals.org/content/42/4/1158.full

https://en.wikipedia.org/wiki/Cerebral_venous_sinus_thrombosis

http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/cerebral_venous_sinus_thrombosis_134,69/

http://circ.ahajournals.org/content/125/13/1704.full

http://radiopaedia.org/articles/cerebral-venous-thrombosis

http://files.www.clotconnect.org/Sinus_Vein_Thrombosis.pdf

http://www.ajnr.org/content/25/10/1676.full

http://pmj.bmj.com/content/76/891/12.long

Uroquinase

https://en.wikipedia.org/wiki/Urokinase

http://www.drugs.com/mtm/urokinase.html

http://www.medicinenet.com/urokinase-injection/article.htm

http://www.drugs.com/sfx/urokinase-side-effects.html

https://en.wikipedia.org/wiki/Urokinase_receptor

Von Willebrandt

http://emedicine.medscape.com/article/206996-overview

https://en.wikipedia.org/wiki/Von_Willebrand_factor

https://en.wikipedia.org/wiki/Von_Willebrand_disease

https://ghr.nlm.nih.gov/gene/VWF

http://www.mayoclinic.org/diseases-conditions/von-willebrand-disease/basics/definition/con-20030195

https://www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Von-Willebrand-Disease